for veterinary use only with a prescription

Tobrofin contains Ketoprofen which is a strong non-steroidal anti-inflammatory drug for horses, camels, & cattle effective in treating colic in horse & mastitis in cattle

COMPOSITION:

Tobrofin contains:

Description:

Ketoprofen is a non-steroidal anti-inflammatory drug belonging to the 2-arylpropionic acid group of NSAIDs, In addition to the anti-inflammatory effect, it also has an anti-pyretic and analgesic effect.

The pharmacological mechanism of action of ketoprofen is based on the inhibition of cyclo-oxygenase and lipoxygenase.

Ketoprofen also prevents the formation of bradykinin and stabilizes the cell membranes of lysosomes, which inhibits the release of lysosomal enzymes that mediate tissue destruction.
Ketoprofen is rapidly absorbed after intramuscular administration.

The measured maximum plasma concentration at 30 minutes from a single dose injection is 16.3 mg/l in swine and 9.7 mg/l in cattle.

Ketoprofen binds approximately 95% to plasma proteins and its bioavailability after intramuscular administration is 80-100%.

The plasma half-life is approximately 1 hour in horses, approximately 2.5 hours in cattle, and 2-3 hours in swine.

Only minor quantities of ketoprofen are transferred to milk.

Ninety percent of the dose is eliminated in the urine primarily as metabolites.

Elimination from the synovial fluid is delayed.

Target species:

Horses, camel, cattle.

Indications:

Horse and Camel: Tobrofin is an Anti-inflammatory and analgesic treatment of musculosceletal disorders. Alleviation of visceral pain associated with colic.
Cattle: Anti-inflammatory treatment of mammary gland disorders.

Contraindications:

Tobrofin is contraindicated in cases of Hypersensitivity to ketoprofen or any of the excipients in the product.

Severe hepatic, renal or cardiac insufficiency, gastro-intestinal ulceration, heavy bleeding or evidence of blood dyscrasia.

Undesirable effects (frequency and seriousness):
Repeated intramuscular injections may cause mild transient irritation.

Due to the mechanism of action of ketoprofen (inhibition of the prostaglandin synthesis), gastric and intestinal irritation or ulceration or renal intolerance may occur.

dosage method of administration:

Horse and camel: 2.2 mg Ketoprofen/kg b.w. /day intravenously.

For example, 11 m/500 kg/day by intravenous injection for up to 3 days.

Cattle: 3 mg Ketoprofen/kg b.w./day intravenously or intramuscularly.

For example, 3 ml/100 kg/day by intravenous or deep intramuscular injection for up to 3 days.

Withdrawal period:

Animals must not be slaughtered for 1 day after the last IV administration with Tobrofin and for 4 days after the last IM administration Withdrawal period for milk is zero (0) day.

Special precautions for storage:

The speciality should be protected from moisture, light and heat.
For animal treatment only.
Keep out of the reach of children.
Do not store Tobrofin above 25 °C.
Protect from light.
Observe aseptic precautions.