الحصن الحصين البيطرية
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Closaverm | Ivermectin and Closantel | veterinary antiparasitic | for cattle and sheep.
for veterinary use only
Closaverm is a veterinary ivermectin and closantel antiparasitic drug for cattle and sheep internal parasites and external parasites which make it effective as cattle and sheep worms treatment including: sheep liver fluke, sheep lungworm and nasal bots in sheep. cattle lungworm, cattle mange and cattle lice treatment. And many more parasites mentioned below..
composition:
Each 1 ml of Closaverm contains:
- Ivermectin 5 mg.
- Closantel 125 mg.
Properties :
-Ivermectin is an endectocide with activity against a wide range of internal and external parasites.
-It enhances the release of gamma amino butyric acid (GABA) at presynaptic neurons.
-GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. By stimulating the release of GABA, ivermectin causes paralysis of the parasite and eventual death.
-Closantel is a member of the salicylanilide class of anthelmintics. Salicylanilides are hydrogen ionophores which act as potent uncouplers of oxidative phosphorylation.
-The site of action of these proton ionophores is known to be selective uncoupling of oxidative phosphorylation in parasite mitochondria.
Indications :
Closaverm is used in Cattle for the treatment of:
-Gastrointestinal roundworms:
Ostertagia ostertagi (including inhibited larval stages), Ostertagia lyrata (adult), Haemonchus placei (adult and immature), Trichostrongylus axei (adult and immature), Trichostrongylus colubriformis (adult and immature), Cooperia oncophora (adult and immature), Cooperia punctata (adult and immature), Cooperia pectinata (adult and immature), Oesophagostomum radiatum (adult and immature), Nematodirus helvetianus (adult), Nematodirus spathiger (adult), Strongyloides papillosus (adult), Bunostomum phlebotomum (adult and immature), Toxocara vitulorum (adult), Trichuris spp.
-Lungworms: Dictyocaulus viviparus ( adult and 4th stage larvae ).
-Liver Fluke (trematodes): Fasciola gigantica, Fasciola hepatica. Eyeworms (adult): Thelazia spp.
Cattle grubs (parasitic stages): Hypoderma bovis, Hypoderma lineatum.
-Lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus.
-Mange Mites: Psoroptes ovis ( syn P communis var bovis ), Sarcoptes scabiei var bovis.
In Sheep Closaverm is used for for the treatment of :
-Gastrointestinal roundworms : Ostertagia circumcincta (including inhibited L4), Ostertagia trifurcata (adult and L4), Haemonchus contortus (including inhibited L4), Trichostrongylus axei (adult), Trichostrongylus colubriformis (adult and L4), T. vitrinus (adult), Cooperia curticei (adult and L4), Oesophagostomum columbianum (adult and L4), O. venulosum (adult), Chabertia ovina (adult and L4), Nematodirus filicollis (adult and L4), Trichuris ovis (adult).
-Lungworms: Dictyocaulus filaria (adult and 4th stage larvae) Protostrongylus rufescens (adult).
-Liver Fluke ( trematodes ) : Fasciola gigantica, Fasciola hepatica.
-Nasal Bots : Oestrus ovis.
-Mange Mites : Psoroptes ovis.
Target Species:
Cattle & Sheep.
Dosage:
Closaverm is given by subcutaneous injection.
1 ml / 25 kg B.Wt. S/C.
Contra-indication & Warnings:
-Not to be used intravenously or intramuscularly.
– in animals producing milk for human consumption, including pregnant animals intended to produce milk for human consumption.
– in cases of known hypersensitivity to the active ingredients.
Side effects:
Transitory swelling has occasionally been observed at the injection site.
Withdrawal Time:
Meat for cattle: 49 days.
for sheep: 28 days.
Vendor Information
- Store Name: الحصن الحصين البيطرية
- Vendor: الحصن الحصين البيطرية
- Address: Riyadh
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