Special warnings

Special warnings for sheep:

-Effectiveness of antimicrobial treatment Foot rot may be reduced by other factors such as wet environmental conditions, as well as inadequate remote management. So, the treatment of foot rot should be done in conjunction with other herd management tools, e.g., providing a dry environment

-Antibiotic treatment of benign foot rot is not appropriate.

Draxxin has shown limited efficacy in sheep with severe clinical signs or chronic foot rot and should, therefore, only be given early on.
Special precautions for use in animals:

-The use of the drug should be based on the susceptibility testing of bacteria isolated from the animal.
-Official, national, and regional antimicrobial policies should be taken into account when using the drug.
Special precautions to be taken by the person administering the veterinary medicinal preparation to animals:
-Tolathromycin is an eye irritant in case of accidental eye exposure; flush immediately with clean water.
-Tolathromycin may cause allergic reactions by contact with the skin. In case of accidental spillage on the skin, wash the skin immediately with soap and water.
– In case of accidental self-injection, seek medical advice immediately and show the package leaflet or label to the doctor.
Pregnancy and lactation: Laboratory studies in rats and rabbits have yielded no evidence of teratogenic or fetotoxic effects or maternal toxicity.

Use only as per benefit/risk assessment by the responsible veterinarian.
-Interaction with other medicinal products and other forms of interaction: Do not use antimicrobials at the same time with a similar mode of action as other macrolides or lincosamides.
-Overdose (symptoms, emergency procedures, antidote): In cattle at doses of three, five, or ten times the recommended dose, transient signs attributable to injection site discomfort were observed and included restlessness, head shaking, ground trampling, and a brief decrease in feed intake.

-Mild myocardial degeneration was observed in cattle receiving 5 to 6 times the recommended dose.

-In piglets weighing approximately 10 kg, when given three or five times the therapeutic dose, transient signs attributable to injection site discomfort were observed and included excessive vocalization and restlessness.

-Lameness was also noted when the hind leg was used as the injection site.

-The drug should not be mixed with other veterinary medicinal products.