– Oxyclear injection is a synergistic combination between Oxytetracycline & Bromhexine.

-Oxytetracycline is a wide spectrum antibiotic, which is widely used for local and systemic infections.
Oxytetracycline has a bacteriostatic action against a large number of aerobic and anaerobic Gram-negative and Gram-positive microorganisms, Rickettsia, Mycoplasma, Chlamydia, Actinomyces and some blood protozoa.

-The bacteriostatic effect is based on the inhibition of the synthesis of bacterial protein.

-Oxytetracycline penetrates very rapidly into the blood and tissues with high concentration and relatively a high percentage of oxytetracycline is bound to serum proteins, therapeutic levels remain in the body for long times.

-Bromhexine is a mucolytic agent which aims to make bronchial secretions easier to propel by ciliary action to expel by coughing and in this way reduce cough frequency.

-It is also of value in achieving liquefaction and improving flow characteristics of mucus by increasing volume and decreasing viscosity.

-It is suggested that bromhexine improves lysosomal function and that lysosomal enzymes hydrolyze the mucopolysaccharide fibres of the mucus.

-The advantage of bromhexine is that it brings about an increase in the content of immunoglobulin and Oxytetracycline in bronchial secretions, presumably by increasing membrane permeability.

-The addition of bromhexine to oxytetracycline (OxyClear) significantly increases the sputum concentration of oxytetracycline which is cleared from plasma more effectively in the presence of bromhexine.

-So the combination of bromhexine with oxytetracycline proves of value in the treatment of certain pulmonary Infections.

-The antibiotic activity is enhanced due to the synergistic action of bromhexine so bromhexine increases the efficacy of oxytetracycline against respiratory infections.