-Rebral is used to combat vitamin B deficiency frequently noted in the ruminant and accentuated by certain factors Insufficient B1 production by the ruminal flora following subacute or chronic lactic acidosis 

-Destruction of B1, synthesized in the rumen, by specific enzymes, the lesions (in parasitic infections)
-Vitamin B1 deficiency is also seen in the milk-fed calves
– B6 plays an important enzymatic role in protein metabolism taking part in the
process of transamination and degradation of amino-acids 

Vitamin B group deficiency, often preceded by digestive troubles, is characterized by nervous symptoms (muscle tremors, grinding of teeth ,hyper excitability eye problems and paralysis).

-Generalised signs are also noted such as loss of appetite, indigestion and bloat