– Neomycin belongs to Aminoglycosides that acts against Gram-negative bacteria as E.coli through irreversibly binding to the 30S subunit of the bacterial ribosome and thereby interfering with several mechanisms in the mRNA translation process.
– Sulfaguanidine belongs to sulfonamides that have been used for the treatment of colibacillosis (E. coli) by interfering with normal production of RNA, protein synthesis and microbial replication mechanism by interfering with folic acid production.
– Kaolin and Pectin have adsorbent ability so it can adsorb and remove bacterial toxins from intestinal mucosa like E. coli toxins which are considered the most important toxin in diarrhea.
– Bismuth subnitrate is a GIT protectant and adsorbent. It is not absorbed from the GIT and acts by lining the mucosal surface and adsorbing toxic products e.g. E. coli enterotoxins.